Featured Journal Publications

Project Data Sphere’s success is ultimately measured by the practice-changing scientific insights discovered by the research community.  We are proud to highlight some of the peer-reviewed publications based on data from the PDS platform that have sparked changes in clinical or research practices.

Article Title Journal
Particle Swarm Optimized Gaussian Process Classifier for Treatment Discontinuation Prediction in Multicohort Metastatic Castration-Resistant Prostate Cancer Patients IEEE Journal of Biomedical and Health Informatics
Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors Journal for ImmunoTherapy of Cancer
Semi-automated Conversion of Clinical Trial Legacy Data into CDISC SDTM Standards Format Using Supervised Machine Learning Methods of Information in Medicine
Immune-related adverse events associated with immune checkpoint inhibitors: a call to action for collecting and sharing clinical trial and real-world data Journal for ImmunoTherapy of Cancer
KMDATA: a curated database of reconstructed individual patient-level data from 153 oncology clinical trials Database
Immune Checkpoint Inhibition in Marjolin Ulcer: A Case Series Journal of Immunotherapy
The Use of External Control Data for Predictions and Futility Interim Analyses in Clinical Trials Neuro-Oncology
Predicting toxicity-related docetaxel discontinuation and overall survival in metastatic castration-resistant prostate cancer: a pooled analysis of open phase 3 clinical trial data Prostate Cancer and Prostatic Diseases
Real-world assessment of response to anti-PD-1 therapy in advanced cutaneous squamous cell carcinoma Journal of the American Academy of Dermatology
Predicting toxicity-related docetaxel discontinuation and survival in metastatic castration-resistant prostate cancer (mCRPC) using open phase III trial data Journal of Clinical Oncology
Adjuvant regional nodal irradiation did not improve outcomes in T1-2N1 breast cancer after breast-conserving surgery: A propensity score matching analysis of BIG02/98 and BCIRG005 trials The Breast
Modeling tumor evolutionary dynamics to predict clinical outcomes for patients with metastatic colorectal cancer; a retrospective analysis American Association of Cancer Research
The VENUSS prognostic model to predict disease recurrence following surgery for non-metastatic papillary renal cell carcinoma: development and evaluation using the ASSURE prospective clinical trial cohort BMC Medicine
Clinical trial data reuse – overcoming complexities in trial design and data sharing Trials

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